2011 Aug;79(8):453-66. doi: 10.1055/s-0031-1273397. 2005 Jan 24;5:5. doi: 10.1186/1471-244X-5-5. Detailed Description: The purpose of this study is to determine whether memantine (Namenda), in doses up to 20 mg/day, will be effective in treating the OCD of adult patients who have not responded to their OCD medication. Male and female patients (N = 50 per disorder, i.e. CONCLUSIONS: This study provides preliminary supportive evidence for the effectiveness of memantine as a glutamatergic augmenting agent in severe OCD. At study end, 6 subjects (42.9%) were responders, and response was achieved by EOW4. This study provides preliminary supportive evidence for the effectiveness of memantine as a glutamatergic augmenting agent in severe OCD. The association of OCD-schizotypal comorbidity with the beneficial effect of memantine is noteworthy in view of a pertinence of glutamatergic dysfunction in both OCD and schizophrenia spectrum disorders (5). Improvement was maintained after 3 months. The previ- We recruited 15 adult subjects with Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition-defined OCD and a baseline Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) of 18 or higher, who had failed to respond to treatment with a serotonin reuptake inhibitor (SRI), given at an adequate and stable dose for at least 12 weeks. [+14 studies from pubmed] Scientific Study. Obsessive-compulsive disorder ... with low doses of dopamine-blocking antipsychotic agents may improve outcomes for patients with treatment-resistant OCD. Thus, attenuating glutamatergic hyperactivity might be beneficial in OCD. 294. Some trials even reported a 100% response! 6, Journal of Clinical Psychopharmacology, Vol. USA.gov. 28, No. Memantine is another augmentation strategy that has been trialed. 43, No. share. COVID-19 is an emerging, rapidly evolving situation. Because of early memantine-related mortality, the 30 and 45 mg/kg/day groups were terminated without further evaluation. in 2012, patients with moderate to severe OCD taking memantine and fluoxetine were more likely to achieve remission after 8 weeks than patients taking placebo and fluoxetine. memantine a gluatame inhibitor failed to ease ocd in this study. The investigators hypothesized that memantine is an effective augmenting agent to standard intensive residential treatment of severe OCD. 108, No. 5, Pharmacology Biochemistry and Behavior, Vol. Obsessive-compulsive symptoms, initially detected at age 16, remitted spontaneously 2 years later. Epub 2008 Aug 15. This thread is archived. Encephale. 132, No. 6, 26 November 2013 | Annals of the New York Academy of Sciences, Vol. The purpose of this study is to determine whether memantine is safe and effective when used as an augmentation to standard treatment for Obsessive-Compulsive Disorder (OCD). 166, No. We report on the first open-label study to test the hypothesis that memantine, a noncompetitive glutamate antagonist, will result in a clinically meaningful reduction in OCD symptoms in adults with treatment-resistant OCD. “The key finding of the present study was that neither adjuvant gabapentin nor adjuvant memantine had better effects on symptoms of OCD than a placebo,” said the researchers. Memantine can help with decreasing the symptoms of OCD but not on its own. Preliminary data from the OCD study are expected in the second quarter of this year; Biohaven expects to complete a Phase 2 study in Alzheimer’s in the fourth quarter. We report a therapeutic effect of add-on memantine, an N-methyl-d-aspartic acid glutamatergic receptor antagonist, in treatment-resistant OCD. The OCD group experienced a significant mean 40.6% reduction in … Poyurovsky M, Koran LM: Obsessive-compulsive disorder (OCD) with schizotypy vs schizophrenia with OCD: diagnostic dilemmas and therapeutic implications. Have anyone here tried memantine for pure o ocd ? Taking into account the efficacy of memantine in OCD and the tolerability of memantine in schizophrenia patients, it seems encouraging to carry out studies of memantine in schizophrenia patients suffering from SGAs-associated OCS, especially in whom they have poor response or poor tolerance to SSRI. Despite the effectiveness of serotonergic compounds in the treatment of obsessive-compulsive disorder, treatment-resistant symptoms remaining in 40 to 60 % of patients present a pressing clinical problem. Investigating the Role of Glutamate in Obsessive-Compulsive Disorder: Current Perspectives. There is a growing body of evidence for the efficacy of memantine augmentation in patients with obsessive-compulsive disorder (OCD). OCD group - received 12 weeks of open-label memantine 10 mg twice daily, as either mono therapy or augmentation of their existing medication. Brief Summary: The objective of this study was to obtain preliminary open-label data on the efficacy and tolerability of memantine, an anti-glutamatergic medication with a unique pharmacodynamic profile, in individuals with OCD and individuals with GAD. J Psychiatr Res 2005; 39:399–408Crossref, Medline, Google Scholar, Current Medicinal Chemistry, Vol. 1, 29 August 2013 | Human Psychopharmacology: Clinical and Experimental, Vol. 2, The Pharmacogenomics Journal, Vol. One study suggests that eight one-hour sessions of mindfulness meditation is beneficial. Another said, “I feel as if the weight of OCD has been lifted.” A … We report a therapeutic effect of add-on memantine, an N-methyl-d-aspartic acid glutamatergic receptor antagonist, in treatment-resistant OCD. There was a substantial reduction in the time occupied by OCD and distress, followed by increased control over obsessions. Add-on memantine was well tolerated and resulted in clinically significant reduction of OCD symptom severity. Mean baseline Y-BOCS score was 27.4 (SD, 5.0). In the randomized withdrawal study (Study B), the adverse reaction in patients randomized to placebo (n=160) and reported in at least 5% of patients and at twice the frequency of the full-dose memantine treatment group (n=157) was irritability (5.0% vs 2.5%). Secondary outcomes of interest included changes in comorbid depression severity as measured by the BDI, psy-chosocial functioning changes as measured by the WSA scale, Goodman WK, Price LH, Rasmussen SA, Mazure C, Delgado P, Heninger GR, Charney DS: The Yale-Brown Obsessive Compulsive Scale, II: validity. It is less preferred than acetylcholinesterase inhibitors such as donepezil. The electronic databases of PubMed, Scopus, Embase and Google Scholar were searched for relevant trials using keywords ‘obsessive-compulsive disorder OR OCD’ AND ‘memantine’. Pallanti S, Hollander E, Goodman WK: A qualitative analysis of nonresponse: management of treatment-refractory obsessive-compulsive disorder. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Our results suggest that memantine as an add-on treatment to antidepressant therapy was beneficial for the treatment of patients with OCD, and memantine was shown to be safe for patients with OCD. 231, No.  |  Question. The most popular drugs for the treatment of OCD are the selective serotonin reuptake inhibitors (SSRIs). Quetiapine augmentation of SRIs in treatment refractory obsessive-compulsive disorder: a double-blind, randomised, placebo-controlled study [ISRCTN83050762]. Fineberg NA, Hollander E, Pallanti S, Walitza S, Grünblatt E, Dell'Osso BM, Albert U, Geller DA, Brakoulias V, Janardhan Reddy YC, Arumugham SS, Shavitt RG, Drummond L, Grancini B, De Carlo V, Cinosi E, Chamberlain SR, Ioannidis K, Rodriguez CI, Garg K, Castle D, Van Ameringen M, Stein DJ, Carmi L, Zohar J, Menchon JM. 2008 Sep;34(4):400-8. doi: 10.1016/j.encep.2008.04.004. The aim of the present study was therefore to assess the effect of adjuvant memantine in a double-blind, randomized and placebo-controlled study of the treatment of patients suffering from OCD. In this study, patients who were not treatment-resistant started memantine concurrently with an SSRI. placebo-controlled study was to further prove the effective-ness of memantine add-on in the treatment of patients suf-fering from OCD and in this case around 31 years of age, and, unlike the study by Ghaleiha et al. J Clin Psychiatry. Memantine is not FDA approved for OCD, but is approved for the treatment of Alzheimer's Disease. Data from the fields of genetics, neuroimaging, and animal studies, along with case reports and small clinical trials, point to a role for glutamatergic dysfunction in the pathophysiology of obsessive-compulsive disorder (OCD). In a randomized double-blind placebo-controlled study of memantine combined with fluoxetine published by Ghaleiha et al. 2020 Jul;35(4):173-193. doi: 10.1097/YIC.0000000000000314. The present study is a broader systematic review and meta-analysis and examines the efficacy of memantine as an augmentation strategy for moderate to severe OCD in recently conducted, single and double blinded as well as open-label trials. Epub 2011 Aug 1. Latinos with obsessive-compulsive disorder: Mental healthcare utilization and inclusion in clinical trials. Wetterneck CT, Little TE, Rinehart KL, Cervantes ME, Hyde E, Williams M. J Obsessive Compuls Relat Disord. Please enable it to take advantage of the complete set of features! Conclusions: This study provides preliminary supportive evidence for the effectiveness of memantine as a glutamatergic augmenting agent in severe OCD. , 10 OCD and seven generalized anxiety disorder (GAD) subjects received 12 wk of open-label memantine (20 mg/d), as either monotherapy or augmentation of their existing medication. Large double-blind placebo-controlled trials are needed to further test our findings. 2017;15(7):977-995. doi: 10.2174/1570159X15666170320104237. In this open-label augmentation trial of memantine in treatment-resistant OCD, almost half the subjects had a meaningful improvement in symptoms. As described in the Privacy Policy and Terms of Use, this website utilizes cookies, including for the purpose of offering an optimal online experience and services tailored to your preferences. 28, No. Management of obsessive-compulsive disorder comorbid with bipolar disorder. potentially impact OCD severity in a time-dependent manner).  |  In a randomized double-blind placebo-controlled study of memantine combined with fluoxetine published by Ghaleiha et al. There is some evidence that memantine can be useful in obsessive-compulsive disorder (OCD). HHS Specifically, in 4 randomized controlled trials (RCTs), the response rate was 81% in 67 memantine-treated patients vs only 19% in 68 placebo-treated patients. 8, No. Clinical advances in obsessive-compulsive disorder: a position statement by the International College of Obsessive-Compulsive Spectrum Disorders. Dr Andrade takes a closer look at the methods the authors used and the studies they included to weigh the merits of their conclusions. NIH Another drug, the N-methyl-d-aspartate antagonist memantine, has recently been tested in the treatment of OCD. 19, No. J Am Acad Child Adolesc Psychiatry 2000; 39:1096–1103Crossref, Medline, Google Scholar, 4. Large double-blind placebo-controlled trials … The diminished symptoms lasted throughout the following week in half of the patients. I am a chronic suffer of Severe OCD, and have read numerous of studies of Memantine being effective for treatment resistant OCD. 29, No. According to some studies, memantine has shown some potential when used in addition to first-line treatments for OCD. 100% Upvoted. The purpose of this study is to determine whether memantine is safe and effective when used as an augmentation to standard treatment for Obsessive-Compulsive Disorder (OCD). Obsessive-compulsive disorder (OCD) is a chronic psychiatric illness and 1 of the most common anxiety disorders with the prevalence of 3%. Posted by 1 month ago. Evidence from genetic, behavioral, and neuroimaging studies have indicated glutamatergic alteration in OCD (2). A reported case study of a 15-year-old female with severe OCD used memantine 5 mg twice daily (bid) in addition to preexisting citalopram. Patients who complete study period II will participate in study period III. Journal of Clinical Psychopharmacology 30 : 34–9. Summary: Future randomized double-blind placebo-controlled trials are warranted. 2020 Apr 17;16:1003-1013. doi: 10.2147/NDT.S211703. Side effects to memantine were mild and transient, and no subject withdrew from the study for an adverse event. Memantine also enhances intracortical inhibition, 23 which is deficient in OCD. J Clin Psychiatry 2004; 65(suppl 14):6–10Google Scholar, 2. It is taken by mouth. 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